Comparative Effectiveness of Dynamic Patterns of Glucose Lowering Therapies

In type 2 diabetes, the maintenance of intensive glucose control typically requires the use of multiple glucose lowering agents including insulin. Over the past decade, the number of available glucose lowering agents has expanded, creating more options and more uncertainty regarding the optimal approach to glucose management. This uncertainty is heightened by concerns regarding possible adverse effects of glucose lowering agents and associated patterns of intensive glucose lowering. This study seeks to describe the basic relationship among care seeking, medication choices, and glucose control, within the Veterans Health Administration (VHA) healthcare system. Specific emphasis will be placed on prescribing patterns, clinical and non-clinical predictors of multiple medication choice and the comparative effectiveness of different drug patterns on health outcomes within a real world setting.

VA Comparative Effectiveness of Glucose Lowering Therapies team

Principal Investigator: Elbert S. Huang, MD, MPH*
Research Team:
Anirban Basu, PhD, University of Washington, co-investigator
Paul Rathouz, PhD, University of Wisconsin,  biostatistics consultant
Min-Woong Sohn, PhD, Hines VA/Northwestern, co-investigator*
Todd A. Lee, PharmD, PhD, VA affiliate, University of Illinois at Chicago, co-investigator
Nicholas Emanuele, MD, HinesVA, Loyola University Chicago, co-investigator
Francesca Cunningham, PharmD, Hines VA / University of Illinois at Chicago, co-investigator
Brian Bartle, MPH, Hines VA, data programmer*
Vishal Ahuja, PhD, Cox School of Business – Southern Methodist University, researcher*
Jennifer Cooper, MPH, project manager*

*pictured above

Funding Source:
Agency for Healthcare Research Quality (AHRQ RO1 HS018542-01A2)