Home Sleep and Circadian Phase: Mediators of Racial Disparities in Diabetes Risk

in-home psgDespite the long-standing recognition of the racial disparity in type 2 diabetes between African Americans and non-Hispanic whites, and the attempts to eliminate it, it persists.  Diabetes is associated with reduced quality of life, decreased life expectancy and increased economic burden, and therefore African Americans experience a greater health burden than non-Hispanic whites.  Laboratory and observational studies have observed (1) significant associations between deficient sleep and increased diabetes risk and (2) shorter sleep durations and poorer sleep quality in African Americans compared to whites. Therefore, we will examine sleep duration, sleep quality and circadian disruption as novel biobehavioral mediators of the racial disparity in diabetes risk.  Thus the 3 primary goals of this study are to (1) conduct comprehensive and ecologically-valid assessments of sleep in people’s homes, (2) assess circadian phase in the home environment and (3) determine if differences in home sleep and circadian measures partially explain differences in diabetes risk factors between African Americans and non-Hispanic whites.

Principal Investigator: Kristen Knutson, PhD
Co-Investigators:
Eve Van Cauter, PhD, Section of Endocrinology
Silvana Pannain, MD, Section of Endocrinology
Babak Mokhlesi, Section of Pulmonary & Critical Care

Funding Source: NIH R01DK095207-01A1